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Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jan 3;80(Pt C):295-303. doi: 10.1016/j.pnpbp.2017.04.034. Epub 2017 Jun 6.

The effects of pessimism on cell-mediated immunity in rats.

Author information

1
Institute of Pharmacology, Polish Academy of Sciences, Department of Experimental Neuroendocrinology, 12 Smetna Street, 31-343 Krakow, Poland.
2
Institute of Pharmacology, Polish Academy of Sciences, Department of Experimental Neuroendocrinology, 12 Smetna Street, 31-343 Krakow, Poland. Electronic address: kubera@if-pan.krakow.pl.
3
Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
4
Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
5
Institute of Pharmacology, Polish Academy of Sciences, Affective Cognitive Neuroscience Lab, Department of Behavioral Neuroscience and Drug Development, 12 Smetna Street, 31-343 Krakow, Poland.

Abstract

We used a recently developed ambiguous-cue interpretation (ACI) paradigm to investigate whether 'optimism' and 'pessimism' as behavioural traits may be interrelated with immune functions in rodents. To this aim, in a series of ACI tests (cognitive bias screening, CBS), we identified rats that displayed 'pessimistic' and 'optimistic' traits. We found significant differences in immune biomarkers between 'optimistic' and 'pessimistic' animals. Moreover 'pessimism' was associated with significantly lower relative weight of the spleen and thymus, significantly decreased proliferative activity of splenocytes. Pessimism was associated with an increased production of interleukin-(IL)1β and IL-4, activin A, l-selectin, interferon (IFN)-γ and some chemokines and receptors for advanced glycation endproducts. The findings indicate an inflammatory profile in "pessimistic" animals.

KEYWORDS:

Ambiguous-cue interpretation; Cognitive judgment bias; Cytokine; Optimism; Pessimism; Spleen

PMID:
28595946
DOI:
10.1016/j.pnpbp.2017.04.034
[Indexed for MEDLINE]

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