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Surg Today. 2017 Dec;47(12):1500-1511. doi: 10.1007/s00595-017-1544-4. Epub 2017 May 29.

Long-term outcome of adipose-derived regenerative cell-enriched autologous fat transplantation for reconstruction after breast-conserving surgery for Japanese women with breast cancer.

Author information

1
Department of Surgery, Kyushu University Beppu Hospital, 4546 Tsurumihara, Beppu, 874-0838, Japan.
2
Ueo Breast Surgical Hospital, Oita, Japan.
3
Hakusan Clinic, Oita, Japan.
4
Cytori Therapeutics, K.K., Tokyo, Japan.
5
Cytori Therapeutics, Inc., San Diego, CA, USA.
6
Department of Surgery, Kyushu University Beppu Hospital, 4546 Tsurumihara, Beppu, 874-0838, Japan. kmimori@beppu.kyushu-u.ac.jp.
7
Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan.

Abstract

PURPOSE:

More effective methods are needed for breast reconstruction after breast-conserving surgery for breast cancer. The aim of this clinical study was to assess the perioperative and long-term outcomes of adipose-derived regenerative cell (ADRC)-enriched autologous fat grafting.

METHODS:

Ten female patients who had undergone breast-conserving surgery and adjuvant radiotherapy for breast cancer were enrolled. An ADRC-enriched fat graft prepared from the patient's adipose tissue was implanted at the time of adipose tissue harvest. The perioperative and long-term outcomes of the grafts, which included safety, efficacy, and questionnaire-based patient satisfaction, were investigated.

RESULTS:

The mean operation time was 188 ± 30 min, and the mean duration of postoperative hospitalization was 1.2 ± 0.4 days. No serious postoperative complications were associated with the procedure. Neither recurrence nor metastatic disease was observed during the follow-up period (7.8 ± 1.5 years) after transplantation. Of 9 available patients, "more than or equal to average" satisfaction with breast appearance and overall satisfaction were reported by 6 (66.7%) and 5 (55.6%) patients, respectively.

CONCLUSIONS:

ADRC-enriched autologous fat transplantation is thus considered to be safe perioperatively, with no long-term recurrence, for patients with breast cancer treated by breast-conserving surgery, and it may be an option for breast reconstruction, even after adjuvant radiotherapy.

KEYWORDS:

Adipose-derived regenerative cell; Breast cancer; Breast reconstruction; Breast-conserving surgery; Quality of life

PMID:
28555267
DOI:
10.1007/s00595-017-1544-4
[Indexed for MEDLINE]

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