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Curr Opin Biotechnol. 2017 Oct;47:7-15. doi: 10.1016/j.copbio.2017.05.005. Epub 2017 May 25.

Engineering cell fitness: lessons for regenerative medicine.

Author information

1
Institute of Biomaterials and Biomedical Engineering (IBBME), University of Toronto, Toronto, Ontario M5S 3E1, Canada.
2
Institute of Biomaterials and Biomedical Engineering (IBBME), University of Toronto, Toronto, Ontario M5S 3E1, Canada; The Donnelly Centre for Cellular and Biomolecular Research (CCBR), University of Toronto, Toronto, Ontario M5S 3E1, Canada; Medicine by Design, University of Toronto, Toronto, Ontario M5S 3G9, Canada. Electronic address: peter.zandstra@utoronto.ca.

Abstract

Cell competition results in the loss of weaker cells and the dominance of stronger cells. So-called 'loser' cells are either removed by active elimination or by limiting their access to survival factors. Recently, competition has been shown to serve as a surveillance mechanism against emerging aberrant cells in both the developing and adult organism, contributing to overall organism fitness and survival. Here, we explore the origins and implications of cell competition in development, tissue homeostasis, and in vitro culture. We also provide a forward look on the use of cell competition to interpret multicellular dynamics while offering a perspective on harnessing competition to engineer cells with optimized and controllable fitness characteristics for regenerative medicine applications.

PMID:
28551499
DOI:
10.1016/j.copbio.2017.05.005
[Indexed for MEDLINE]
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