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Int J Biol Macromol. 2017 Oct;103:1130-1137. doi: 10.1016/j.ijbiomac.2017.05.101. Epub 2017 May 18.

Composite poly(lactic acid)/chitosan nanofibrous scaffolds for cardiac tissue engineering.

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College of Food Science, Sichuan Agricultural University, Yaan 625014, PR China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, PR China. Electronic address:
College of Food Science, Sichuan Agricultural University, Yaan 625014, PR China.


Fibrous scaffolds with different ratios of poly (lactic acid) (PLA) and chitosan were fabricated by conventional electrospinning. After crosslinking by the glutaraldehyde vapor, the structure, mechanical properties, hydrophilicity, and in-fiber chemical interactions of the scaffolds were investigated. We found that the fiber diameter decreased with the concentration of chitosan, while mechanical properties and hydrophilicity improved. In addition, we found that scaffolds with aligned fibers have higher mechanical strength and biocompatibility than scaffolds with randomly oriented fibers. In particular, scaffolds with aligned fibers with PLA:chitosan ratios of 7:1 was found to support cardiomyocyte viability, elicit cell elongation, and enhance production of sarcomeric α-actinin and troponin I. Collectively, the data indicate that composite scaffolds consisting of PLA/chitosan fibers have great potential for engineering cardiac tissue, and for accelerating the regeneration of myocardia.


Aligned fibers; Chitosan; Poly(lactic acid)

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