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Nat Rev Neurosci. 2017 Jul;18(7):419-434. doi: 10.1038/nrn.2017.48. Epub 2017 May 18.

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease.

Author information

1
Zilkha Neurogenetic Institute, 1501 San Pablo Street, Los Angeles, California 90089, USA.

Abstract

Cerebral blood flow (CBF) regulation is essential for normal brain function. The mammalian brain has evolved a unique mechanism for CBF control known as neurovascular coupling. This mechanism ensures a rapid increase in the rate of CBF and oxygen delivery to activated brain structures. The neurovascular unit is composed of astrocytes, mural vascular smooth muscle cells and pericytes, and endothelia, and regulates neurovascular coupling. This Review article examines the cellular and molecular mechanisms within the neurovascular unit that contribute to CBF control, and neurovascular dysfunction in neurodegenerative disorders such as Alzheimer disease.

PMID:
28515434
PMCID:
PMC5759779
DOI:
10.1038/nrn.2017.48
[Indexed for MEDLINE]
Free PMC Article

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