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J Turk Ger Gynecol Assoc. 2017 Mar 15;18(1):1-8. doi: 10.4274/jtgga.2016.0138.

Do clinical data and human papilloma virus genotype influence spontaneous regression in grade I cervical intraepithelial neoplasia?

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Department of Obstetrics and Gynecology, Complex Hospital of Albacete University, Albacete, Spain.
Department of Obstetrics and Gynecology, La Fe University and Polytechnic Hospital, Valencia, Spain.
Department of Pathological Anatomy, Reina Sofia General University Hospital, Murcia, Spain.



To determine whether medical history, clinical examination and human papilloma virus (HPV) genotype influence spontaneous regression in cervical intraepithelial neoplasia grade I (CIN-I).


We retrospectively evaluated 232 women who were histologically diagnosed as have CIN-I by means of Kaplan-Meier curves, the pattern of spontaneous regression according to the medical history, clinical examination, and HPV genotype.


Spontaneous regression occurred in most patients and was influenced by the presence of multiple HPV genotypes but not by the HPV genotype itself. In addition, regression frequency was diminished when more than 50% of the cervix surface was affected or when an abnormal cytology was present at the beginning of follow-up.


The frequency of regression in CIN-I is high, making long-term follow-up and conservative management advisable. Data from clinical examination and HPV genotyping might help to anticipate which lesions will regress.


Human papilloma virus; cervical intraepithelial neoplasia grade I; human papilloma virus genotyping; regression low-grade squamous intraepithelial lesion.

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