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Mitochondrion. 2017 Sep;36:85-95. doi: 10.1016/j.mito.2017.05.002. Epub 2017 May 9.

Photostimulation of mitochondria as a treatment for retinal neurodegeneration.

Author information

1
School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK; Cardiff Institute for Tissue Engineering and Repair, Cardiff University, Cardiff, UK. Electronic address: BeirneK@cardiff.ac.uk.
2
School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK; Cardiff Institute for Tissue Engineering and Repair, Cardiff University, Cardiff, UK. Electronic address: RozanowskaMB@cardiff.ac.uk.
3
School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK; Cardiff Institute for Tissue Engineering and Repair, Cardiff University, Cardiff, UK; Cardiff Eye Unit, University Hospital of Wales, Cardiff, UK. Electronic address: VotrubaM@cardiff.ac.uk.

Abstract

Absorption of photon energy by neuronal mitochondria leads to numerous downstream neuroprotective effects. Red and near infrared (NIR) light are associated with significantly less safety concerns than light of shorter wavelengths and they are therefore, the optimal choice for irradiating the retina. Potent neuroprotective effects have been demonstrated in various models of retinal damage, by red/NIR light, with limited data from human studies showing its ability to improve visual function. Improved neuronal mitochondrial function, increased blood flow to neural tissue, upregulation of cell survival mediators and restoration of normal microglial function have all been proposed as potential underlying mechanisms of red/NIR light.

KEYWORDS:

Low-level light therapy; Near infrared light; Neurodegeneration; Photobiomodulation; Photostimulation; Red light; Retina

PMID:
28499983
DOI:
10.1016/j.mito.2017.05.002
[Indexed for MEDLINE]

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