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Ann N Y Acad Sci. 2017 Apr;1394(1):106-127. doi: 10.1111/nyas.13356.

Gambling disorder: an integrative review of animal and human studies.

Author information

1
New York State Psychiatric Institute, New York, New York.
2
Department of Psychiatry, Columbia University, New York, New York.
3
Departments of Neuroscience and Pharmacology, Columbia University, New York, New York.
4
Division of Epidemiology, Services and Prevention Research, National Institute on Drug Abuse, Rockville, Maryland.

Abstract

Gambling disorder (GD), previously called pathological gambling and classified as an impulse control disorder in DSM-III and DSM-IV, has recently been reclassified as an addictive disorder in the DSM-5. It is widely recognized as an important public health problem associated with substantial personal and social costs, high rates of psychiatric comorbidity, poor physical health, and elevated suicide rates. A number of risk factors have been identified, including some genetic polymorphisms. Animal models have been developed in order to study the underlying neural basis of GD. Here, we discuss recent advances in our understanding of the risk factors, disease course, and pathophysiology. A focus on a phenotype-based dissection of the disorder is included in which known neural correlates from animal and human studies are reviewed. Finally, current treatment approaches are discussed, as well as future directions for GD research.

KEYWORDS:

animal models; gambling disorder; impulsivity; pathological gambling

PMID:
28486792
PMCID:
PMC5466885
DOI:
10.1111/nyas.13356
[Indexed for MEDLINE]
Free PMC Article

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