Format

Send to

Choose Destination
J Diabetes Complications. 2017 Jul;31(7):1115-1126. doi: 10.1016/j.jdiacomp.2017.04.019. Epub 2017 Apr 21.

The effect of vitamin D supplementation on glucose metabolism in type 2 diabetes mellitus: A systematic review and meta-analysis of intervention studies.

Author information

1
Division of Endocrinology, Diabetes & Metabolism, The Johns Hopkins University, Baltimore, MD, USA. Electronic address: clee158@jhmi.edu.
2
The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
3
Division of Endocrinology, Diabetes & Metabolism, The Johns Hopkins University, Baltimore, MD, USA.
4
The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Division of Infectious Diseases, The Johns Hopkins University, Baltimore, MD, USA; Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA.
5
Division of Rheumatology, The Johns Hopkins University, Baltimore, MD, USA.
6
The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Abstract

AIMS:

We aimed to assess whether vitamin D supplementation improves glucose metabolism in adults with type 2 diabetes.

METHODS:

PubMed and Cochrane database were searched up to July 1st 2016 for randomized controlled trials that assessed the relationship between vitamin D supplementation and glucose metabolism (change in hemoglobin A1C (HbA1C) and fasting blood glucose (FBG)) among adults with type 2 diabetes.

RESULTS:

Twenty nine trials (3324 participants) were included in the systematic review. Among 22 studies included in the meta-analysis, 19 reported HbA1C, 16 reported FBG outcomes and 15 were deemed poor quality. There was a modest reduction in HbA1C (-0.32% [-0.53 to -0.10], I2=91.9%) compared to placebo after vitamin D supplementation but no effect on FBG (-2.33mg/dl [-6.62 to 1.95], I2=59.2%). In studies achieving repletion of vitamin D deficiency (n=7), there were greater mean reductions in HbA1C (-0.45%, [-1.09 to 0.20]) and FBG (-7.64mg/dl [-16.25 to 0.97]) although not significant.

CONCLUSIONS:

We found a modest reduction of HbA1C after vitamin D treatment in adults with type 2 diabetes albeit with substantial heterogeneity between studies and no difference in FBG. Larger studies are needed to further evaluate the glycemic effects of vitamin D treatment especially in patients with vitamin D deficiency.

KEYWORDS:

Glucose metabolism; Randomized controlled trials; Systematic review; Type 2 diabetes; Vitamin D

PMID:
28483335
PMCID:
PMC6016376
DOI:
10.1016/j.jdiacomp.2017.04.019
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center