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Front Mol Neurosci. 2017 Mar 23;10:83. doi: 10.3389/fnmol.2017.00083. eCollection 2017.

Genome Wide Association Study (GWAS) between Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD).

Author information

1
Unit on Statistical Genomics, National Institute of Mental Health, National Institutes of Health (NIH) Bethesda, MD, USA.
2
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine Baltimore, MD, USA.
3
Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health Baltimore, MD, USA.
4
Department of Psychiatry, Faculty of Medicine, University of Toronto Toronto, ON, Canada.
5
New York State Psychiatric Institute, College of Physicians and Surgeons at Columbia University New York, NY, USA.
6
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine Los Angeles, CA, USA.
7
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School Boston, MA, USA.
8
Laboratory of Clinical Science, National Institute of Mental Health Bethesda, MD, USA.
9
Department of Psychiatry and Behavioral Sciences, Keck School of Medicine at the University of Southern California Los Angeles, CA, USA.
10
Department of Psychiatry, University of British Columbia Vancouver, BC, Canada.
11
Department of Biomedicine and Center for Integrated Sequencing (iSEQ), Aarhus UniversityAarhus, Denmark; Department of Biostatistics, Harvard School of Public HealthBoston, MA, USA; Department of Genomic Mathematics, University of BonnBonn, Germany.
12
State Key Laboratory of Genetic Engineering, Life Science Institutes, Fudan University Shanghai, China.

Abstract

Objective: The aim of this study was to identify any potential genetic overlap between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). We hypothesized that since these disorders share a sub-phenotype, they may share common risk alleles. In this manuscript, we report the overlap found between these two disorders. Methods: A meta-analysis was conducted between ADHD and OCD, and polygenic risk scores (PRS) were calculated for both disorders. In addition, a protein-protein analysis was completed in order to examine the interactions between proteins; p-values for the protein-protein interaction analysis was calculated using permutation. Conclusion: None of the single nucleotide polymorphisms (SNPs) reached genome wide significance and there was little evidence of genetic overlap between ADHD and OCD.

KEYWORDS:

ADHD; GWAS; OCD; eQTL; meta-analysis; polygenic score; protein-protein link analysis

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