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J Dent. 2017 May;60:1-7. doi: 10.1016/j.jdent.2017.03.006. Epub 2017 Mar 24.

Developmental defects of enamel and dental caries in the primary dentition: A systematic review and meta-analysis.

Author information

1
Postgraduate Program in Dentistry and Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil. Electronic address: francinesct@gmail.com.
2
Postgraduate Program in Dentistry, Federal University of Pelotas, Pelotas, Brazil. Electronic address: ethieli2@gmail.com.
3
College in Dentistry, Faculdade Especializada na Área de Saúde do Rio Grande do Sul, Passo Fundo, Brazil. Electronic address: gabipinto@gmail.com.
4
Federal University of Pelotas and Section of Periodontology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark. Electronic address: gustavo.gnascimento@hotmail.com.
5
Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand. Electronic address: murray.thomson@otago.ac.nz.
6
Postgraduate Program in Dentistry and Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil. Electronic address: ffdemarco@gmail.com.

Abstract

OBJECTIVES:

This systematic review and meta-analysis evaluated the association between developmental defects of enamel and dental caries in the primary dentition.

SOURCES:

Electronic searches were performed in PubMed, Web of Knowledge, Scopus and Scielo for the identification of relevant studies.

STUDY SELECTION:

Observational studies that examined the association between developmental defects of enamel and dental caries in the deciduous dentition were included. Additionally, meta-analysis, funnel plots and sensitivity analysis were employed to synthesize the available evidence. Multivariable meta-regression analysis was performed to explore heterogeneity among studies.

DATA:

A total of 318 articles were identified in the electronic searches. Of those, 16 studies were included in the meta-analysis. Pooled estimates revealed that children with developmental defects of enamel had higher odds of having dental caries (OR 3.32; 95%CI 2.41-4.57), with high heterogeneity between studies (I2 80%). Methodological characteristic of the studies, such as where it was conducted, the examined teeth and the quality of the study explained about 30% of the variability. Concerning type of defect, children with hypoplasia and diffuse opacities had higher odds of having dental caries (OR 4.28; 95%CI 2.24-8.15; OR1.42; 95%CI 1.15-1.76, respectively).

CONCLUSIONS:

This systematic review and meta-analysis demonstrates a clear association between developmental defects of enamel and dental caries in the primary dentition.

KEYWORDS:

Deciduous teeth; Dental caries; Developmental defects of enamel; Pediatric dentistry; Primary dentition

PMID:
28347809
DOI:
10.1016/j.jdent.2017.03.006
[Indexed for MEDLINE]

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