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Pharmacogenomics. 2017 Apr;18(5):421-426. doi: 10.2217/pgs-2017-0028. Epub 2017 Mar 27.

Institutional profile: University of Florida Health Personalized Medicine Program.

Author information

1
Department of Pharmacotherapy & Translational Research, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.
2
Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA.
3
Clinical & Translational Science Institute, University of Florida, Gainesville, FL 32610, USA.
4
Department of Pharmaceutical Outcomes & Policy, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.
5
Department of Pharmacy, University of Florida Health Shands Hospital, Gainesville, FL 32608, USA.
6
Department of Epidemiology, Colleges of Medicine & Public Health & Health Professions, University of Florida, Gainesville, FL 32610, USA.
7
Department of Psychiatry, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
8
Department of Medicine, College of Medicine, University of Florida, Jacksonville, FL 32209, USA.
9
Department of Pathology, Immunology & Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
10
Department of Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.

Abstract

The University of Florida (UF) Health Personalized Medicine Program launched in 2012 with CYP2C19 genotyping for clopidogrel response at UF Health Shands Hospital. We have since expanded CYP2C19 genotyping to UF Health Jacksonville and established the infrastructure at UF Health to support clinical implementation for five additional gene-drug pairs: TPMT-thiopurines, IFNL3 (IL28B)-PEG IFN-α-based regimens, CYP2D6-opioids, CYP2D6/CYP2C19-antidepressants and CYP2C19-proton pump inhibitors. We are contributing to the evidence based on outcomes with genotype-guided therapy through pragmatic studies of our clinical implementations. In addition, we have developed a broad array of educational programs for providers, trainees and students that incorporate personal genotype evaluation to enhance participant learning.

KEYWORDS:

PEG-interferon; clopidogrel; education; genotype; implementation; opioids; pharmacogenetics; proton pump inhibitors; selective serotonin uptake inhibitors; thiopurines

PMID:
28346068
PMCID:
PMC5558508
DOI:
10.2217/pgs-2017-0028
[Indexed for MEDLINE]
Free PMC Article

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