Format

Send to

Choose Destination
Magn Reson Med. 2018 Jan;79(1):256-263. doi: 10.1002/mrm.26669. Epub 2017 Mar 13.

High-resolution dynamic oxygen-17 MR imaging of mouse brain with golden-ratio-based radial sampling and k-space-weighted image reconstruction.

Author information

1
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
2
Case Center for Imaging Research, Case Western Reserve University, Cleveland, Ohio, USA.
3
Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA.
4
Department of Chemistry, Case Western Reserve University, Cleveland, Ohio, USA.
5
Department of Neurology, Case Western Reserve University, Cleveland, Ohio, USA.
6
Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, USA.

Abstract

PURPOSE:

The current study aimed to develop a three-dimensional (3D) dynamic oxygen-17 (17 O) MR imaging method with high temporal and spatial resolution to delineate the kinetics of 17 O water uptake and washout in the brains of mice with glioblastoma (GBM).

METHODS:

A 3D imaging method with a stack-of-stars golden-ratio-based radial sampling scheme was employed to acquire 17 O signal in vivo. A k-space-weighted image reconstruction method was used to improve the temporal resolution while preserving spatial resolution. Simulation studies were performed to validate the method. Using this method, the kinetics of 17 O water uptake and washout in the brains of mice with GBM were delineated after an intravenous bolus injection of 17 O water.

RESULTS:

The proposed 17 O imaging method achieved an effective temporal resolution of 7.56 s with a nominal voxel size of 5.625 μL in the mouse brain at 9.4 T. Reduced uptake and prolonged washout of 17 O water were observed in tumor tissue, suggesting compromised cerebral perfusion.

CONCLUSION:

This study demonstrated a promising dynamic 17 O imaging approach that can delineate 17 O water kinetics in vivo with high temporal and spatial resolution. It can also be used to image cerebral oxygen consumption rate in oxygen-17 inhalation studies. Magn Reson Med 79:256-263, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

KEYWORDS:

golden-ratio-based radial sampling; k-space-weighted image contrast reconstruction; oxygen-17 MRI

PMID:
28295552
DOI:
10.1002/mrm.26669
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center