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Future Microbiol. 2017 Mar;12:271-283. doi: 10.2217/fmb-2016-0158. Epub 2017 Feb 24.

Clinical and molecular epidemiology of Acinetobacter baumannii bloodstream infections in an endemic setting.

Author information

1
Unit of Infectious Diseases, Assaf Harofeh Medical Center, Zerifin, Israel.
2
Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
3
NIBN, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
4
Clinical Microbiology Laboratory, Assaf Harofeh Medical Center, Zerifin, Israel.
5
Instituto de Microbiologia & Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
6
Public Health Services, Ministry of Health, Jerusalem, Israel.
7
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
8
ESCMID Study Group for Genomic & Molecular Diagnostics (ESGMD), Basel, Switzerland.

Abstract

AIM:

The transmission dynamics of Acinetobacter baumannii in endemic settings, and the relation between microbial properties and patients' clinical outcomes, are yet obscure and hampered by insufficient metadata.

METHODS & RESULTS:

Of 20 consecutive patients with A. baumannii bloodstream infection that were thoroughly analyzed at a single center, at least one transmission opportunity was evident for 85% of patients. This implies that patient-to-patient transmission is the major mode of A. baumannii acquisitions in health facilities. Moreover, all patients who died immediately (<24 h of admission) were infected with a single clone (ST457; relative risk = 1.6; p = 0.05).

CONCLUSION:

This preliminary analysis should prompt further investigation by mapping genomic virulence determinants among A. baumannii ST457 lineage compared with other strains.

KEYWORDS:

Gram-negative; MDR; MLST; carbapenem; nonfermenter; nosocomial infections; typing

PMID:
28287300
DOI:
10.2217/fmb-2016-0158
[Indexed for MEDLINE]

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