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J Invest Dermatol. 2017 Aug;137(8):1638-1645. doi: 10.1016/j.jid.2017.02.977. Epub 2017 Mar 9.

TNF-α Antagonist and Vascular Inflammation in Patients with Psoriasis Vulgaris: A Randomized Placebo-Controlled Study.

Author information

1
Innovaderm Research, Incorporated, Montreal, Quebec, Canada. Electronic address: rbissonnette@innovaderm.ca.
2
Montreal Heart Institute Research Center, Université de Montréal, Montreal, Quebec, Canada.
3
Laboratory of Investigative Dermatology, Rockefeller University, New York, New York, USA.
4
Montreal Health Innovations Coordinating Center (MHICC), Montreal, Quebec, Canada.
5
Innovaderm Research, Incorporated, Montreal, Quebec, Canada.
6
Dr Isabelle Delorme, Incorporated, Drummondville, Quebec, Canada.
7
Lynderm Research, Incorporated, Markham, Ontario, Canada.

Abstract

Vascular inflammation is increased in patients with psoriasis. This randomized, double-blind, multicenter study evaluated the effects of tumor necrosis factor-α antagonist adalimumab on vascular inflammation in patients with psoriasis. A total of 107 patients were randomized (1:1) to receive adalimumab for 52 weeks or placebo for 16 weeks followed by adalimumab for 52 weeks. Vascular inflammation was assessed with positron emission tomography-computed tomography. There were no differences in the change from baseline in vessel wall target-to-background ratio (TBR) from the ascending aorta (primary endpoint) (adalimumab: TBR = 0.002, 95% confidence interval [CI] = -0.048 to 0.053; placebo: TBR = -0.002, 95% CI = -0.053 to 0.049; P = 0.916) and the carotids (adalimumab: TBR = 0.031, 95% CI = -0.005 to 0.066; placebo: TBR = 0.018, 95% CI = -0.019 to 0.055; P = 0.629) at week 16 between adalimumab and placebo. After 52 weeks of treatment with adalimumab there was no significant change from start of treatment in TBR from the ascending aorta (TBR = -0.006, 95% CI = -0.049 to 0.038; P = 0.796), but there was an increase in TBR in carotids (TBR = 0.027, 95% CI = 0.000 to 0.054; P = 0.046). This study showed no difference over 16 weeks in vascular inflammation in patients treated with a tumor necrosis factor-α antagonist or placebo and a modest increase in vascular inflammation in carotids after 52 weeks of treatment with adalimumab.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT01722214.

PMID:
28286061
DOI:
10.1016/j.jid.2017.02.977
[Indexed for MEDLINE]
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