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Trends Endocrinol Metab. 2017 Jun;28(6):437-448. doi: 10.1016/j.tem.2017.02.006. Epub 2017 Mar 6.

Neural Circuit Mechanisms Underlying Emotional Regulation of Homeostatic Feeding.

Author information

1
Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA.
2
Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA. Electronic address: yangyun@upstate.edu.

Abstract

The neural circuits controlling feeding and emotional behaviors are intricately and reciprocally connected. Recent technological developments, including cell type-specific optogenetic and chemogenetic approaches, allow functional characterization of genetically defined cell populations and neural circuits in feeding and emotional processes. Here we review recent studies that have utilized circuit-based manipulations to decipher the functional interactions between neural circuits controlling feeding and those controlling emotional processes. Specifically, we highlight newly described neural circuit interactions between classical emotion-related brain regions, such as the hippocampus and amygdala, and homeostatic feeding circuitry in the arcuate nucleus and lateral hypothalamus (LH). Together these circuits will provide a template for future studies to examine functional interactions between feeding and emotion.

PMID:
28279562
PMCID:
PMC5438765
DOI:
10.1016/j.tem.2017.02.006
[Indexed for MEDLINE]
Free PMC Article

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