Send to

Choose Destination
JAMA. 2017 Mar 7;317(9):967-968. doi: 10.1001/jama.2017.0001.

Opioid Agonist Treatment for Patients With Dependence on Prescription Opioids.

Author information

National Drug and Alcohol Centre, University of New South Wales, Sydney, Australia.
Discipline of Addiction Medicine, University of Sydney, Sydney, Australia.


Clinical Question:

Are different opioid agonist treatments (eg, methadone vs buprenorphine) associated with differences in efficacy for treating prescription opioid dependence, and is long-term maintenance of opioid agonist treatment associated with differences in efficacy compared with opioid taper or psychological treatments alone?

Bottom Line:

For patients who are dependent on prescription opioids, long-term maintenance of opioid agonists is associated with less prescription opioid use and better adherence to medication and psychological therapies for opioid dependence compared with opioid taper or psychological treatments alone. Methadone maintenance was not associated with differences in therapeutic efficacy compared with buprenorphine maintenance treatment. Evidence quality was low to moderate.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center