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Neurology. 2017 Mar 28;88(13):1282-1290. doi: 10.1212/WNL.0000000000003761. Epub 2017 Mar 1.

Clinical implications of the melanopsin-based non-image-forming visual system.

Author information

1
From the Departments of Neurological Surgery (A.K., I.J.P.) and Neurology and Neuroscience (J.J.P.), University of Virginia Health Sciences Center, Charlottesville; Surgical Neurology Branch (A.K., K.A.Z.), National Institutes of Neurological Disorders and Stroke, NIH, Bethesda, MD; and the Departments of Molecular Physiology and Biological Physics (A.K.) and Biology (I.P.), University of Virginia, Charlottesville. alex@virginia.edu.
2
From the Departments of Neurological Surgery (A.K., I.J.P.) and Neurology and Neuroscience (J.J.P.), University of Virginia Health Sciences Center, Charlottesville; Surgical Neurology Branch (A.K., K.A.Z.), National Institutes of Neurological Disorders and Stroke, NIH, Bethesda, MD; and the Departments of Molecular Physiology and Biological Physics (A.K.) and Biology (I.P.), University of Virginia, Charlottesville.

Abstract

Since the discovery of the non-image-forming visual system, tremendous research efforts have been dedicated to understanding its mechanisms and functional roles. Original functions associated with the melanopsin system include the photoentrainment of circadian sleep-wake cycles and the pupillary light reflex. Recent findings, however, suggest a much broader involvement of this system in an array of physiologic responses to light. This newfound insight into the underlying function of the non-image-forming system has revealed the many connections to human pathology and attendant disease states, including seasonal affective disorder, migraine, glaucoma, inherited mitochondrial optic neuropathy, and sleep dysregulation of aging. In this review, the authors discuss in detail the clinical implications of the melanopsin system.

PMID:
28251921
PMCID:
PMC5373779
DOI:
10.1212/WNL.0000000000003761
[Indexed for MEDLINE]
Free PMC Article

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