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Psychoneuroendocrinology. 2017 Apr;78:151-158. doi: 10.1016/j.psyneuen.2017.01.027. Epub 2017 Jan 27.

Associations between hippocampal morphology, diffusion characteristics, and salivary cortisol in older men.

Author information

1
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK; Department of Psychology, University of Edinburgh, UK; Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Edinburgh, UK.
2
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK; Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Edinburgh, UK; Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, UK. Electronic address: M.Valdes_Hernan@ed.ac.uk.
3
School of Computing, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea.
4
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK; Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Edinburgh, UK; Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, UK.
5
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK; Department of Psychology, University of Edinburgh, UK.
6
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK; Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Edinburgh, UK; Edinburgh Delirium Research Group, Geriatric Medicine, University of Edinburgh, UK.
7
Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, UK; Department of Computer Science, Lagos State University, Lagos, Nigeria.
8
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK.
9
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK; Edinburgh Delirium Research Group, Geriatric Medicine, University of Edinburgh, UK.

Abstract

High, unabated glucocorticoid (GC) levels are thought to selectively damage certain tissue types. The hippocampus is thought to be particularly susceptible to such effects, and though findings from animal models and human patients provide some support for this hypothesis, evidence for associations between elevated GCs and lower hippocampal volumes in older age (when GC levels are at greater risk of dysregulation) is inconclusive. To address the possibility that the effects of GCs in non-pathological ageing may be too subtle for gross volumetry to reliably detect, we analyse associations between salivary cortisol (diurnal and reactive measures), hippocampal morphology and diffusion characteristics in 88 males, aged ∼73 years. However, our results provide only weak support for this hypothesis. Though nominally significant peaks in morphology were found in both hippocampi across all salivary cortisol measures (standardised β magnitudes<0.518, puncorrected>0.0000003), associations were both positive and negative, and none survived false discovery rate correction. We found one single significant association (out of 12 comparisons) between a general measure of hippocampal diffusion and reactive cortisol slope (β=0.290, p=0.008) which appeared to be driven predominantly by mean diffusivity but did not survive correction for multiple testing. The current data therefore do not clearly support the hypothesis that elevated cortisol levels are associated with subtle variations in hippocampal shape or microstructure in non-pathological older age.

KEYWORDS:

3D shape analysis; Ageing; Brain; Cortisol; Hippocampus; MRI

PMID:
28199858
PMCID:
PMC5380197
DOI:
10.1016/j.psyneuen.2017.01.027
[Indexed for MEDLINE]
Free PMC Article

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