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Phys Rev Lett. 2017 Jan 27;118(4):048002. doi: 10.1103/PhysRevLett.118.048002. Epub 2017 Jan 27.

Giant Acceleration of DNA Diffusion in an Array of Entropic Barriers.

Author information

1
Department of Physics, Brown University, Providence, Rhode Island 02912, USA.
2
Division of Applied Mathematics, Brown University, Providence, Rhode Island 02912, USA.
3
Computational Science and Engineering Laboratory, Department of Mechanical and Process Engineering, CH-8092 ETH Z├╝rich, Switzerland.

Abstract

We investigate with experiments and computer simulations the nonequilibrium dynamics of DNA polymers crossing arrays of entropic barriers in nanofluidic devices in a pressure-driven flow. With increasing driving pressure, the effective diffusivity of DNA rises and then peaks at a value that is many times higher than the equilibrium diffusivity. This is an entropic manifestation of "giant acceleration of diffusion." The phenomenon is sensitive to the effective energy landscape; thus, it offers a unique probe of entropic barriers in a system driven away from equilibrium.

PMID:
28186790
DOI:
10.1103/PhysRevLett.118.048002
[Indexed for MEDLINE]

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