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Nat Immunol. 2017 Apr;18(4):412-421. doi: 10.1038/ni.3683. Epub 2017 Feb 6.

Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation.

Author information

1
Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.
2
Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, New York, USA.
3
Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York, USA.
4
Department of Electrical Engineering and Computer Science and Center for Computational Biology, University of California, Berkeley, Berkeley, California, USA.
5
Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.
6
Department of Biology, New York University, New York, New York, USA.
7
Center for Human Microbial Ecology, Translational Health Science and Technology Institute (an autonomous institute of Department of Biotechnology, Govt. of India), NCR Biotech Science Cluster, Faridabad, India.

Abstract

Type 1 regulatory T cells (Tr1 cells) are induced by interleukin-27 (IL-27) and have critical roles in the control of autoimmunity and resolution of inflammation. We found that the transcription factors IRF1 and BATF were induced early on after treatment with IL-27 and were required for the differentiation and function of Tr1 cells in vitro and in vivo. Epigenetic and transcriptional analyses revealed that both transcription factors influenced chromatin accessibility and expression of the genes required for Tr1 cell function. IRF1 and BATF deficiencies uniquely altered the chromatin landscape, suggesting that these factors serve a pioneering function during Tr1 cell differentiation.

PMID:
28166218
PMCID:
PMC5901650
DOI:
10.1038/ni.3683
[Indexed for MEDLINE]
Free PMC Article

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