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Philos Trans R Soc Lond B Biol Sci. 2017 Mar 19;372(1716). pii: 20160183. doi: 10.1098/rstb.2016.0183.

Ribosome pausing, arrest and rescue in bacteria and eukaryotes.

Author information

1
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Howard Hughes Medical Institute, Baltimore, MD, USA.
2
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Howard Hughes Medical Institute, Baltimore, MD, USA ragreen@jhmi.edu.

Abstract

Ribosomes translate genetic information into polypeptides in several basic steps: initiation, elongation, termination and recycling. When ribosomes are arrested during elongation or termination, the cell's capacity for protein synthesis is reduced. There are numerous quality control systems in place to distinguish between paused ribosomes that need some extra input to proceed and terminally stalled ribosomes that need to be rescued. Here, we discuss similarities and differences in the systems for resolution of pauses and rescue of arrested ribosomes in bacteria and eukaryotes, and how ribosome profiling has transformed our ability to decipher these molecular events.This article is part of the themed issue 'Perspectives on the ribosome'.

KEYWORDS:

Dom34/PELO; EFP; Hbs1/HBS1l; Rli1/ABCE1; eIF5A; tmRNA

PMID:
28138069
PMCID:
PMC5311927
DOI:
10.1098/rstb.2016.0183
[Indexed for MEDLINE]
Free PMC Article

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