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Nat Neurosci. 2017 Mar;20(3):385-388. doi: 10.1038/nn.4491. Epub 2017 Jan 30.

Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress.

Author information

1
Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
2
Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
3
Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, Texas, USA.
4
Department of Integrative Biology and Pharmacology, University of Texas Health Sciences Center, Houston, Texas, USA.
5
Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel.

Abstract

The hypothalamic-pituitary-adrenal axis is a pivotal component of an organism's response to stressful challenges, and dysfunction of this neuroendocrine axis is associated with a variety of physiological and psychological pathologies. We found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic-pituitary-adrenal axis regulation that prepares the organism for successive exposure to stressful stimuli.

PMID:
28135239
DOI:
10.1038/nn.4491
[Indexed for MEDLINE]

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