Abstract
Fifteen new phloroglucinol derivatives, jamunones A-O (1-8 and 10-16, respectively), along with one known analogue spiralisone C (9), were isolated from Eugenia jambolana seeds. Their structures were elucidated by detailed nuclear magnetic resonance and mass spectrometry spectroscopic data interpretation. Compounds 1-9, 11, 12, and 14-16 inhibited protein tyrosine phosphatase 1B activity with IC50 values ranging from 0.42 to 3.2 μM.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
India
-
Inhibitory Concentration 50
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Phloroglucinol* / analogs & derivatives
-
Phloroglucinol* / isolation & purification
-
Phloroglucinol* / pharmacology
-
Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors*
-
Seeds / chemistry*
-
Syzygium / chemistry*
Substances
-
Phloroglucinol
-
PTPN1 protein, human
-
Protein Tyrosine Phosphatase, Non-Receptor Type 1