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Curr Biol. 2017 Feb 6;27(3):437-444. doi: 10.1016/j.cub.2016.12.016. Epub 2017 Jan 19.

Plant Stress Tolerance Requires Auxin-Sensitive Aux/IAA Transcriptional Repressors.

Author information

1
Section of Cell and Developmental Biology and Howard Hughes Medical Institute, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Department of Molecular Biology and Ecology of Plants, Tel Aviv University, Tel Aviv 69978, Israel.
2
Section of Cell and Developmental Biology and Howard Hughes Medical Institute, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
3
Department of Molecular Biology and Ecology of Plants, Tel Aviv University, Tel Aviv 69978, Israel.
4
Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
5
Department of Molecular and Structural Biology, North Carolina State University, Raleigh, NC 27695, USA.
6
Genome Analysis Laboratory, Howard Hughes Medical Institute and The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
7
Section of Cell and Developmental Biology and Howard Hughes Medical Institute, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: mestelle@ucsd.edu.

Abstract

The Aux/IAA proteins are auxin-sensitive repressors that mediate diverse physiological and developmental processes in plants [1, 2]. There are 29 Aux/IAA genes in Arabidopsis that exhibit unique but partially overlapping patterns of expression [3]. Although some studies have suggested that individual Aux/IAA genes have specialized function, genetic analyses of the family have been limited by the scarcity of loss-of-function phenotypes [4]. Furthermore, with a few exceptions, our knowledge of the factors that regulate Aux/IAA expression is limited [1, 5]. We hypothesize that transcriptional control of Aux/IAA genes plays a central role in the establishment of the auxin-signaling pathways that regulate organogenesis, growth, and environmental response. Here, we describe a screen for transcription factors (TFs) that regulate the Aux/IAA genes. We identify TFs from 38 families, including 26 members of the DREB/CBF family. Several DREB/CBF TFs directly promote transcription of the IAA5 and IAA19 genes in response to abiotic stress. Recessive mutations in these IAA genes result in decreased tolerance to stress conditions, demonstrating a role for auxin in abiotic stress. Our results demonstrate that stress pathways interact with the auxin gene regulatory network (GRN) through transcription of the Aux/IAA genes. We propose that the Aux/IAA genes function as hubs that integrate genetic and environmental information to achieve the appropriate developmental or physiological outcome.

KEYWORDS:

Aux/IAA; abiotic stress; auxin; plant hormone; repressor

PMID:
28111153
PMCID:
PMC5296222
DOI:
10.1016/j.cub.2016.12.016
[Indexed for MEDLINE]
Free PMC Article

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