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Curr Opin Biotechnol. 2017 Aug;46:20-26. doi: 10.1016/j.copbio.2016.10.011. Epub 2017 Jan 11.

Exploiting molecular motors as nanomachines: the mechanisms of de novo and re-engineered cytoskeletal motors.

Author information

1
Department of Biological Sciences, Smith College, Northampton, MA 01063, United States; School of Natural Science, Hampshire College, Amherst, MA 01002, United States.
2
Department of Biological Sciences, Smith College, Northampton, MA 01063, United States; Center for Microscopy and Imaging, Smith College, Northampton, MA 01063, United States. Electronic address: nderr@smith.edu.

Abstract

Cytoskeletal molecular motors provide exciting proof that nanoscale transporters can be highly efficient, moving for microns along filamentous tracks by hydrolyzing ATP to fuel nanometer-size steps. For nanotechnology, such conversion of chemical energy into productive work serves as an enticing platform for re-purposing and re-engineering. It also provides a roadmap for successful molecular mechanisms that can be mimicked to create de novo molecular motors for nanotechnology applications. Here we focus specifically on how the mechanisms of molecular motors are being re-engineered for greater control over their transport parameters. We then discuss mechanistic work to create fully synthetic motors de novo and conclude with future directions in creating novel motor systems.

PMID:
28088100
DOI:
10.1016/j.copbio.2016.10.011
[Indexed for MEDLINE]

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