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Cell Host Microbe. 2017 Jan 11;21(1):1-2. doi: 10.1016/j.chom.2016.12.013.

Knotty Zika Virus Blocks Exonuclease to Produce Subgenomic Flaviviral RNAs.

Author information

1
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
2
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: stacy.horner@duke.edu.

Abstract

In a recent issue of Science, Akiyama et al. (2016) prove the existence of a pseudoknot that stabilizes a nuclease-resistant RNA structure in the 3' untranslated region of Zika virus. This reinforced structure blocks the 5'→3' exonuclease Xrn1 for the production of pathogenic subgenomic flaviviral RNAs.

KEYWORDS:

RNA structure; Xrn1; Zika virus; sfRNA; xrRNA

PMID:
28081439
PMCID:
PMC6123830
DOI:
10.1016/j.chom.2016.12.013
[Indexed for MEDLINE]
Free PMC Article

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