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Nat Rev Genet. 2017 Mar;18(3):180-191. doi: 10.1038/nrg.2016.156. Epub 2017 Jan 3.

Ground rules of the pluripotency gene regulatory network.

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Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
Universidad Católica San Antonio de Murcia (UCAM) Campus de los Jerónimos, No. 135 Guadalupe 30107, Murcia, Spain.
Division of Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia.


Pluripotency is a state that exists transiently in the early embryo and, remarkably, can be recapitulated in vitro by deriving embryonic stem cells or by reprogramming somatic cells to become induced pluripotent stem cells. The state of pluripotency, which is stabilized by an interconnected network of pluripotency-associated genes, integrates external signals and exerts control over the decision between self-renewal and differentiation at the transcriptional, post-transcriptional and epigenetic levels. Recent evidence of alternative pluripotency states indicates the regulatory flexibility of this network. Insights into the underlying principles of the pluripotency network may provide unprecedented opportunities for studying development and for regenerative medicine.

[Indexed for MEDLINE]

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