Format

Send to

Choose Destination
Curr Opin Neurobiol. 2017 Feb;42:75-83. doi: 10.1016/j.conb.2016.11.009. Epub 2016 Dec 12.

Division modes and physical asymmetry in cerebral cortex progenitors.

Author information

1
Univ Lyon, Universite Claude Bernard Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, 69500 Bron, France.
2
Anatomy and Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.
3
Univ Lyon, Universite Claude Bernard Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, 69500 Bron, France. Electronic address: Colette.dehay@inserm.fr.
4
Laboratory for Cell Asymmetry, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan. Electronic address: fumio@cdb.riken.jp.

Abstract

Neural stem cells go through a sequence of timely regulated gene expression and pattern of division mode to generate diverse neurons during brain development. During vertebrate cerebral cortex development, neural stem cells begin with proliferative symmetric divisions, subsequently undergo neurogenic asymmetric divisions, and finally gliogenic divisions. In this review, we explore the relationship between stem cell versus neural fate specification and the division mode. Specifically, we discuss recent findings on the mechanisms of asymmetric divisions, division mode, and developmental progression of neural progenitor identity.

PMID:
27978481
DOI:
10.1016/j.conb.2016.11.009
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center