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J Magn Reson Imaging. 2017 Jun;45(6):1617-1626. doi: 10.1002/jmri.25513. Epub 2016 Nov 10.

Crossover comparison of ferumoxytol and gadobenate dimeglumine for abdominal MR-angiography at 3.0 tesla: Effects of contrast bolus length and flip angle.

Author information

1
Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
2
Clinic of Radiology and Nuclear Medicine, Basel University Hospital, Basel, Switzerland.
3
Department of Radiology, University of Yamanashi, Yamanashi, Japan.
4
Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Germany.
5
Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
6
Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
7
Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
8
Department of Emergency Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
9
Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Abstract

PURPOSE:

Ferumoxytol (FE) has gained interest as an alternative to gadolinium-based contrast agents (GBCAs). The purpose of this study was to evaluate and optimize ferumoxytol dose and T1 weighting, in comparison to a conventional GBCA.

MATERIALS AND METHODS:

Twelve healthy volunteers (six women / six men, mean age 44.3 years) were recruited for this study. Scanning was performed on a clinical 3 Tesla (T) MRI system. Gadobenate dimeglumine (GD)-enhanced MRA was performed followed by FE-enhanced MRA 1 month later. Volunteers were randomly assigned to a diluted (n = 6) or undiluted (n = 6) dose of GD (0.1 mmol/kg), and to FE doses of 4 mg/kg (n = 6) or 2 mg/kg (n = 6). First pass and steady-state MRA were performed for GD- and FE-enhanced MRA. Flip-angle optimization was performed after FE administration. Quantitative analysis included relative contrast-to-noise ratio (relCNR) measurements for all acquisitions. First pass GD- and FE-enhanced MRA images were evaluated qualitatively.

RESULTS:

RelCNR was significantly higher with undiluted GD (31.8, 95% confidence interval [CI], 27.7-35.9) compared with diluted GD (16.2; 95% CI, 12.2-20.3; P = 0.001) and both 4 mg/kg FE (12.5; 95% CI, 8.5-16.4; P < 0.001) and 2 mg/kg FE (9.1; 95% CI, 5.1-13.2; P < 0.001) during first pass. Relative CNR did not decrease with FE 5 min postinjection compared with GD. Flip-angle analysis revealed relative CNR-peaks at 30° for FE 4 mg/kg and at 20° for FE 2 mg/kg. Diluted GD (P = 0.013) and FE 4 mg/kg (P = 0.01) revealed significantly higher image quality scores compared with undiluted GD during first pass.

CONCLUSION:

This study shows an equivalent image quality of FE and GD for first pass MRA even though GD showed significantly higher relative CNR.

LEVEL OF EVIDENCE:

1 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;45:1617-1626.

KEYWORDS:

contrast dilution; contrast dose; ferumoxytol; gadobenate dimeglumine

PMID:
27862577
PMCID:
PMC5425329
DOI:
10.1002/jmri.25513
[Indexed for MEDLINE]
Free PMC Article

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