Format

Send to

Choose Destination
Nat Genet. 2016 Dec;48(12):1535-1543. doi: 10.1038/ng.3704. Epub 2016 Oct 31.

Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.

Author information

1
Swiss Tropical and Public Health Institute, Basel, Switzerland.
2
University of Basel, Switzerland.
3
Forschungszentrum Borstel, Germany.
4
Institut Pasteur de Tunis, Université de Tunis El Manar, Tunis, Tunisia.
5
The Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Institutes of Biomedical Sciences and Institute of Medical Microbiology, School of Basic Medical Science of Fudan University, Shanghai, China.
6
Institute for Social and Preventive Medicine, University of Bern, Switzerland.
7
Laboratory of Infection and Immunity, School of Basic Medical Science, West China Center of Medical Sciences, Sichuan University, Chengdu, Sichuan 610041, China.
8
School of Medicine, University of California, San Francisco, USA.
9
Laboratòrio de Saùde Publica, Lisbon, Portugal.
10
Hospital Nossa Senhora Da Paz, Cubal, Benguela, Angola.
11
Servei de Microbiologia, Hospital Clínic-ISGlobal, Barcelona, Spain.
12
Victorian Infectious Diseases Reference Laboratory, Victoria, Australia.
13
Ifakara Health Institute, Bagamoyo, Tanzania.
14
Public Health Ontario, Toronto, Canada.
15
Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
16
Department of Medical Microbiology, Makerere University, Kampala, Uganda.
17
Department of Global Health, University of Amsterdam, Amsterdam, the Netherlands.
18
Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, USA.
19
LabPlus, Auckland City Hospital, Auckland, New Zealand.
20
Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal.
21
ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
22
Oswaldo Cruz Institute, Brazil.
23
Institute of Infectious Disease and Molecular Medicine and Department of Clinical Laboratory Sciences, University of Cape Town, South Africa.
24
Department of Medicine, Imperial College London, UK.
25
The Francis Crick Institute Mill Hill Laboratory, London, UK.
26
Papua New Guinea Institute of Medical Research, Goroka, PNG.
27
Insitute of Tropical Medicine, Antwerp, Belgium.
28
Tartu University Hospital United Laboratories, Mycobacteriology, Tartu, Estonia.
29
Clinical Research Department, Epicentre, Paris, France.
30
Department of Microbiology, University Hospital La Fe, Valencia, Spain.
31
Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
32
Institute Laboratory for Tuberculosis Research (LTR), Biotechnology Center (BTC), University of Yaoundé I, Yaoundé, Cameroon.
33
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
34
Department of Medical Laboratory Technology, Faculty of Medical Technology, Baghdad, Iraq.
35
Institute of Tropical Medicine and Infectious Diseases (ITROMID), Jomo Kenyatta University of Agriculture and Technology (JKUAT), Nairobi, Kenya.
36
Department of Pathology, Aga Khan University Hospital (AKUH), Nairobi, Kenya.
37
Medical Research Council, Fajara, the Gambia.
38
Fondation Congolaise pour la Recherche Médicale, Université Marien Gouabi, Brazzaville, Congo.
39
Right to Care and the Clinical HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
40
National Institute of Medical Research, Mbeya Medical Research Centre (NIMR-MMRC), Mbeya, Tanzania.
41
Division of Infectious Diseases and Tropical Medicine, Medical Centre of the University of Munich, Munich, Germany; German Centre for Infection Research (DZIF), partner site Munich, Germany.
42
Emerging Bacterial Pathogens Unit, IRCCS, San Raffaele Scientific Institute, Milan, Italy.
43
Riga East University Hospital, Centre of Tuberculosis and Lung Diseases, Riga, Latvia.
44
WHO Supranational TB Reference Laboratory, Department of Microbiology, The Public Health Agency of Sweden, Solna, Sweden.
45
Department of Immunology and Cell Biology, Institute of Biotechnology, Vilnius University, Vilnius, Lithuania.
46
Institute for Epidemiology, Schleswig-Holstein University Hospital, Kiel, Germany.
47
National Tuberculosis Reference Laboratory, Phthysiopneumology Institute, Chisinau, Republic of Moldova.
48
'Marius Nasta' Pneumophtisiology Institute, Bucharest, Romania.
49
Department of Infection and Immunity, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
50
Instituto de Medicina Tropical Alexander von Humboldt, Molecular Epidemiology Unit-Tuberculosis, Universidad Peruana Cayetano Heredia, Lima, Peru.
51
Alpert School of Medicine at Brown University, Providence, Rhode Island, USA.
52
Moi University School of Medicine, Eldoret, Kenya.
53
Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France.
54
Institute of Biomedicine of Valencia (IBV-CSIC), 46010, Valencia, Spain.
55
CIBER Epidemiology and Public Health, Madrid, Spain.
56
German Center for Infection Research, Borstel Site, Borstel, Germany.
#
Contributed equally

Abstract

Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.

PMID:
27798628
PMCID:
PMC5238942
DOI:
10.1038/ng.3704
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center