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Semin Immunol. 2016 Oct;28(5):431-440. doi: 10.1016/j.smim.2016.09.005. Epub 2016 Oct 24.

Adipose tissue at the nexus of systemic and cellular immunometabolism.

Author information

1
Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
2
Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland. Electronic address: llynch@bwh.harvard.edu.

Abstract

At the simplest interpretation of the word, Immunometabolism describes the intersection of the fields of immunology and metabolism. With rapidly growing interest in this field, the term has expanded, and now encompasses a variety of concepts and definitions shaped by an individual's scientific area of expertise, cell-type and tissue of interest, and biological approach. One scientist may be interested in investigating the intrinsic metabolic checkpoints that drive a M1 versus M2 macrophage response, while another may be interested in how macrophages affect systemic metabolism during obesity. Although both interests have very different foci, they both reflect the current interests in immunometabolism and studies over the last decade have uncovered new metabolic nodes that dictate the course of effector fate within cells, as well as an unexpected role for the immune system in controlling systemic metabolism. Thus, immunometabolism is at the frontier for many novel therapeutic targets to control both cell intrinsic and whole body metabolism in many diseases including cancer, diabetes, obesity, and sepsis among others. In this review, we hope to break down the word immunometabolism into two main themes: whole-body metabolism and cellular bioenergetics. In each instance we will focus on the adipose tissue and its resident immune cells to illustrate recent advances in both sectors of immunometabolism.

KEYWORDS:

Adipose tissue; Cellular bioenergetics; Diabetes; Immunometabolism; Obesity

PMID:
27789087
DOI:
10.1016/j.smim.2016.09.005
[Indexed for MEDLINE]

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