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Biomed Res Int. 2016;2016:6456031. Epub 2016 Sep 29.

Epidemiology of American Tegumentary Leishmaniasis and Trypanosoma cruzi Infection in the Northwestern Argentina.

Author information

1
Instituto de Investigaciones en Enfermedades Tropicales, Sede Regional Orán, Universidad Nacional de Salta, 4530 Salta, Argentina.
2
Instituto de Investigaciones en Enfermedades Tropicales, Sede Regional Orán, Universidad Nacional de Salta, 4530 Salta, Argentina; Instituto de Patología Experimental (IPE-CONICET), Facultad de Ciencias de la Salud, Universidad Nacional de Salta, 4400 Salta, Argentina.
3
Instituto de Patología Experimental (IPE-CONICET), Facultad de Ciencias de la Salud, Universidad Nacional de Salta, 4400 Salta, Argentina.
4
Instituto de Biología de la Altura (InBiAl), Universidad Nacional de Jujuy, Jujuy, Argentina.
5
Instituto de Investigaciones en Enfermedades Tropicales, Sede Regional Orán, Universidad Nacional de Salta, 4530 Salta, Argentina; Cátedra de Química Biológica, Facultad de Ciencias Naturales, Universidad Nacional de Salta, 4400 Salta, Argentina.
6
Instituto de Investigaciones en Enfermedades Tropicales, Sede Regional Orán, Universidad Nacional de Salta, 4530 Salta, Argentina; Instituto de Investigaciones en Energía no Convencional (INENCO-CONICET), Universidad Nacional de Salta, 4400 Salta, Argentina.

Abstract

Background. Endemic areas of tegumentary leishmaniasis (TL) in Salta, Argentina, present some overlap zones with the geographical distribution of Chagas disease, with mixed infection cases being often detected. Objectives. The purpose of this study was to determine the magnitude of Leishmania sp. infection and potential associated risk factors, the serologic prevalence of T. cruzi, and the presence of T. cruzi-Leishmania sp. mixed infection in a region of the northwest of Argentina. Methods. Cross-sectional studies were conducted to detect TL prevalence and T. cruzi seroprevalence. A case-control study was conducted to examine leishmaniasis risk factors. Results. Prevalence of TL was 0.17%, seroprevalence of T. cruzi infection was 9.73%, and mixed infection proportion-within the leishmaniasic patients group-was 16.67%. The risk factors associated with TL transmission were sex, age, exposure to bites at work, staying outdoors more than 10 hours/day, bathing in the river, and living with people who had lesions or were infected during the study. Discussion. The endemic pattern of TL seems to involve exposure of patients to vectors in wild as well as peridomestic environment. Cases of T. cruzi infection are apparently due to migration. Therefore, a careful epidemiological surveillance is necessary due to the contraindication of antimonial administration to chagasic patients.

PMID:
27777950
PMCID:
PMC5061991
DOI:
10.1155/2016/6456031
[Indexed for MEDLINE]
Free PMC Article

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