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Cell. 2016 Oct 20;167(3):604-605. doi: 10.1016/j.cell.2016.10.008.

Glucagon and Thyroid Hormone: A Championship Team.

Author information

1
Salk Institute for Biological Studies, Clayton Foundation Laboratories for Peptide Biology, 10010 N. Torrey Pines Rd, La Jolla, CA 92037, USA. Electronic address: asaghatelian@salk.edu.
2
Department of Chemical Physiology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: cravatt@scripps.edu.

Abstract

A bioactive peptide that combines glucagon with the thyroid hormone T3 lowers lipid levels, improves glucose tolerance, and promotes energy expenditure to treat symptoms and underlying causes of metabolic disease. The two active components both maximize their combined benefits and mitigate the negative consequences of treatment with each alone.

PMID:
27768884
DOI:
10.1016/j.cell.2016.10.008
[Indexed for MEDLINE]
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