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Oncotarget. 2017 Jan 24;8(4):7175-7180. doi: 10.18632/oncotarget.12739.

The concept of immune surveillance against tumors. The first theories.

Author information

1
Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy.
2
National Cancer Institute "Giovanni Paolo II", Bari, Italy.

Abstract

The immune system plays a major role in the surveillance against tumors. To avoid attack from the immune system, tumor cells develop different strategies to escape immune surveillance. Evidence of immune surveillance comes from both animal models and clinical observations. Mice with a wide variety of immunodeficiencies have a high rate of tumor incidence and are more susceptible to transplanted or chemical carcinogen-induced tumors. Immunosuppressed patients have a high incidence of tumors. However, many patients develop cancer even in the presence of an apparently normal immune system. This indicates that tumor cells are able to escape immune surveillance. The aim of this review article is to summarize the literature concerning the development of the theory of immune surveillance against tumors; to discuss the evidence for and against this theory, and to discuss the concept of immunoediting. Finally, the current approaches in anti-tumor immunotherapy will be analyzed.

KEYWORDS:

Antigen; T cell; history of medicine; immune surveillance; tumor

PMID:
27764780
PMCID:
PMC5351698
DOI:
10.18632/oncotarget.12739
[Indexed for MEDLINE]
Free PMC Article

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