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Sleep. 2016 Nov 1;39(11):1985-1992.

A Longitudinal Twin and Sibling Study of Associations between Insomnia and Depression Symptoms in Young Adults.

Author information

1
Department of Psychology, Goldsmiths, University of London, London, UK.
2
MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK.
3
Department of Psychiatry, School of Medicine, University of Pittsburgh.
4
MRC Harwell, UK.
5
Sleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, Sir William Dunn School of Pathology, University of Oxford, UK.

Abstract

STUDY OBJECTIVES:

To estimate genetic and environmental influences on the associations between insomnia and depression symptoms concurrently and longitudinally.

METHODS:

Behavioral genetic analyses were conducted on data from the British longitudinal G1219 twin/sibling study. One thousand five hundred fiftysix twins and siblings participated at Time 1 (mean age = 20.3 years, SD = 1.76). Eight hundred sixty-two participated at Time 2 (mean age = 25.2 years, SD = 1.73 years). Participants completed the Insomnia Symptoms Questionnaire and the Short Mood and Feelings Questionnaire to assess symptoms of insomnia and depression respectively.

RESULTS:

Genetic effects accounted for 33% to 41% of the variance of the phenotypes. The phenotypic correlations were moderate (r = 0.34 to r = 0.52). The genetic correlations between the variables were high (0.73-1.00). Genetic effects accounted for a substantial proportion of the associations between variables (50% to 90%). Non-shared environmental effects explained the rest of the variance and covariance of the traits.

CONCLUSIONS:

While genetic effects play a modest role in insomnia and depression symptoms separately, they appear to play a more central role in concurrent and longitudinal associations between these phenotypes. This should be acknowledged in theories explaining these common associations.

KEYWORDS:

depression; genetics; insomnia; longitudinal; twins

PMID:
27634812
PMCID:
PMC5070752
DOI:
10.5665/sleep.6228
[Indexed for MEDLINE]
Free PMC Article

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