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Cell. 2016 Sep 8;166(6):1362-1364. doi: 10.1016/j.cell.2016.08.058.

Probing the Diversity of T Cell Dysfunction in Cancer.

Author information

1
Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
2
Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA. Electronic address: susan.kaech@yale.edu.

Abstract

T cell dysfunction in cancer comes in many forms, with two new varieties reported in this issue. Daley et al. find that T cells expressing γδ T cell receptors (TCR) promote pancreatic tumor growth by inhibiting activation of T cells with conventional TCRs. Singer et al. characterize dysfunctional tumor infiltrating lymphocytes to reveal a role for zinc homeostasis in anti-tumor immunity.

PMID:
27610560
PMCID:
PMC5523106
DOI:
10.1016/j.cell.2016.08.058
[Indexed for MEDLINE]
Free PMC Article

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