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Science. 2016 Sep 9;353(6304):1108. doi: 10.1126/science.aaf5663.

Comment on "Principles of connectivity among morphologically defined cell types in adult neocortex".

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159C Mellon Institute, Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA.
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA.
Neuroscience Paris Seine (NPS), Cortical Network and Neurovascular Coupling (CNNC), CNRS UMR 8246, Inserm U 1130, UPMC UM 119, Université Pierre et Marie Curie, 9 Quai Saint Bernard, 75005 Paris, France.
Laboratorio Cajal de Circuitos Corticales, Centro de Tecnologia Biomedica, Universidad Politecnica de Madrid, Campus Montegancedo S/N, Pozuelo de Alarcon, 28223 Madrid, Spain. Instituto Cajal (CSIC), Avenida Doctor Arce 37, 28002 Madrid, Spain.
Institut für Neurowissenschaften und Medizin (INM-2), Forschungszentrum Jülich, 52425 Jülich, Germany.
Department of Cellular and Network Neurobiology, Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1450 Budapest, POB 67, Hungary.
Division of Cerebral Circuitry, National Institute for Physiological Sciences, 5-1 Myodaiji-Higashiyama, Okazaki, Aichi 444-8787, Japan.
University of Debrecen, Department of Anatomy, Histology, Embryology, Laboratory for Cortical Systems Neuroscience, Nagyerdei krt. 98, 4012 Debrecen, Hungary.
Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, 35 Convent Drive MSC3715, Bethesda, MD 20892, USA.
Max Planck Institute for Biological Cybernetics, Computational Neuroanatomy Group, D-72076 Tubingen, Germany.
Neuroscience Paris Seine, Univerisité Pierre et Marie Curie (UPMC) Paris VI, 7-9 Quai Saint Bernard, 75005 Paris, France.
Neuroscience Institute, Department of Anesthesiology, Perioperative Care, and Pain Medicine, New York University School of Medicine, Smilow Research Center, 522 First Avenue, New York, NY 10016, USA.
University Medicine Goettingen, Center for Anatomy, Institute for Neuroanatomy, Kreuzbergring 36, D-37075 Goettingen, Germany.
Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3TH, UK.
Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép Fasor 52, Szeged, H-6726 Hungary.
Kavli institute of Brain Science, Columbia University, Department of Biological Sciences, West 120 Street, New York, NY 10027, USA.


Jiang et al (Research Article, 27 November 2015, aac9462) describe detailed experiments that substantially add to the knowledge of cortical microcircuitry and are unique in the number of connections reported and the quality of interneuron reconstruction. The work appeals to experts and laypersons because of the notion that it unveils new principles and provides a complete description of cortical circuits. We provide a counterbalance to the authors' claims to give those less familiar with the minutiae of cortical circuits a better sense of the contributions and the limitations of this study.

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