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Clin Nucl Med. 2016 Oct;41(10):789-91. doi: 10.1097/RLU.0000000000001331.

Brain Metastases Mimicking Hyperostosis Frontalis Interna on 99mTc HDP Bone Scintigraphy.

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From the *Department of Nuclear Medicine, Chonnam National University Hospital, and †Chonnam National University Hwasun Hospital, Gwangju; and ‡Chonbuk National University Hospital, Jeonju, Republic of Korea.


Symmetric bifrontal uptake of bone-seeking agents is usually considered as the main feature of hyperostosis frontalis interna in postmenopausal elderly women. This finding is not uncommon in elderly women because of the change in their hormonal level. However, in the present case, a 66-year-old woman with intra-axial brain metastases of breast cancer showed symmetric bifrontal uptake on bone scintigraphy. Therefore, symmetric bifrontal uptake should not always be considered as a definite indicator of hyperostosis frontalis interna. Further evaluation such as SPECT/CT is needed for evaluation of brain metastases especially in cancer patients.

[Indexed for MEDLINE]

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