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Bioessays. 2016 Nov;38(11):1167-1176. doi: 10.1002/bies.201600008. Epub 2016 Aug 24.

The gut-skin axis in health and disease: A paradigm with therapeutic implications.

Author information

1
Dermatology Research Centre, Institute of Inflammation and Repair, University of Manchester and Manchester Academic Health Sciences Centre, Manchester, UK. catherine.a.oneill@manchester.ac.uk.
2
Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
3
Gastrointestinal Research Centre, Institute of Inflammation and Repair, University of Manchester and Manchester Academic Health Sciences Centre, Manchester, UK.
4
Dermatology Research Centre, Institute of Inflammation and Repair, University of Manchester and Manchester Academic Health Sciences Centre, Manchester, UK.
5
Department of Dermatology, University of Münster, Münster, Germany.

Abstract

As crucial interface organs gut and skin have much in common. Therefore it is unsurprising that several gut pathologies have skin co-morbidities. Nevertheless, the reason for this remains ill explored, and neither mainstream gastroenterology nor dermatology research have systematically investigated the 'gut-skin axis'. Here, in reviewing the field, we propose several mechanistic levels on which gut and skin may interact under physiological and pathological circumstances. We focus on the gut microbiota, with its huge metabolic capacity, and the role of dietary components as potential principle actors along the gut-skin axis. We suggest that metabolites from either the diet or the microbiota are skin accessible. After defining open key questions around the nature of these metabolites, how they are sensed, and which cutaneous changes they can induce, we propose that understanding of these pathways will lead to novel therapeutic strategies based on targeting one organ to improve the health of the other.

KEYWORDS:

diet; gut; microbiota; probiotic; skin

PMID:
27554239
DOI:
10.1002/bies.201600008
[Indexed for MEDLINE]

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