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Photodermatol Photoimmunol Photomed. 2016 Sep;32(5-6):247-253. doi: 10.1111/phpp.12266. Epub 2016 Sep 27.

Comparison of the efficacy of 308-nm excimer lamp monotherapy with topical tacrolimus or clobetasol 17-propionate combination therapies in localized vitiligo.

Author information

1
Department of Dermatology, Gazi University Hospital, Ankara, Turkey.

Abstract

BACKGROUND:

In recent years, excimer light treatments have come to the fore in localized vitiligo because of their high efficacy and safety.

OBJECTIVE:

We aimed to evaluate the efficacy of 308-nm excimer lamp as a monotherapy and its combination with tacrolimus 0.1% or clobetasol 17-propionate 0.05% ointment in localized vitiligo.

METHODS:

We performed a retrospective study including a total of 82 patients who were treated with excimer lamp monotherapy (EL group) (n = 30), excimer lamp + topical tacrolimus (EL + T group) (n = 29), or excimer lamp + topical clobetasol 17-propionate (EL + CS group) (n = 23). We used digital morphometric analysis for the evaluation of repigmentation.

RESULTS:

Median healing rate after 24 sessions was significantly higher in EL + T group (69%) than EL (42.5%) and EL + CS (44%) groups (P = 0.008 and P = 0.032). There were not any patients with face lesions in EL + CS group, so when these patients were excluded, EL + T and EL + CS groups had higher healing rates than EL group (P = 0.037 and P = 0.043). It was confirmed that combination with tacrolimus was superior to clobetasol-17 propionate (P = 0.048) with multivariate regression analysis.

CONCLUSION:

We noted that 308-nm excimer lamp therapy was efficacious; adding topical tacrolimus or topical clobetasol-17 propionate could increase response to treatment.

KEYWORDS:

308-nm excimer; clobetasol-17 propionate; digital morphometric analysis; tacrolimus; vitiligo

PMID:
27552312
DOI:
10.1111/phpp.12266
[Indexed for MEDLINE]

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