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Exp Hematol. 2016 Oct;44(10):908-12. doi: 10.1016/j.exphem.2016.06.254. Epub 2016 Jul 15.

Inflammatory signals in HSPC development and homeostasis: Too much of a good thing?

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Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Headington, Oxford, United Kingdom.
Australian Centre for Blood Diseases, Monash University, Melbourne, Australia.
Division of Hematology, University Hospital and University of Zurich, Zurich, Switzerland.
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.
Section of Infectious Diseases, Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, TX.
Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO. Electronic address:


Hematopoietic stem cells (HSCs) reside in the bone marrow and are responsible for the lifetime maintenance of the blood and bone marrow, achieved through their differentiation into the myriad cellular components and their ability to generate additional stem cells via self-renewal. Identification of intrinsic and extrinsic factors that regulate how the HSC population is maintained over the lifespan of an organism, or those that trigger differentiation into mature hematopoietic cell types, are important goals for regenerative medicine. Recent studies have found that inflammatory signals play a role in the regulation of adult HSC homeostasis and tonic innate immune signals influence HSC development during embryogenesis. Additionally, dysregulation of inflammatory cytokines, and the consequent impact of this on hematopoietic progenitors, may be a contributing factor to the hematopoietic defects that occur during aging and in patients with bone marrow failure syndromes or blood cancers. To update recent findings on this topic, the International Society for Experimental Hematology (ISEH) organized a webinar entitled "The Role of Inflammatory Signals in Embryonic HSC Development and Adult HSC Function," which we summarize here.

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