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J Nat Prod. 2016 Jul 22;79(7):1872-6. doi: 10.1021/acs.jnatprod.6b00229. Epub 2016 Jul 11.

Polybrominated Diphenyl Ethers: Structure Determination and Trends in Antibacterial Activity.

Author information

1
Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, Maryland 20892-0820, United States.
2
Coral Reef Research Foundation , Koror, PW 96940, Palau.

Abstract

Antibacterial-guided fractionation of the Dictyoceratid sponges Lamellodysidea sp. and two samples of Dysidea granulosa yielded 14 polybrominated, diphenyl ethers including one new methoxy-containing compound (8). Their structures were elucidated by interpretation of spectroscopic data of the natural product and their methoxy derivatives. Most of the compounds showed strong antimicrobial activity with low- to sub-microgram mL(-1) minimum inhibitory concentrations against drug-susceptible and drug-resistant strains of Staphylococcus aureus and Enterococcus faecium, and two compounds inhibited Escherichia coli in a structure-dependent manner.

PMID:
27399938
PMCID:
PMC6201272
DOI:
10.1021/acs.jnatprod.6b00229
[Indexed for MEDLINE]
Free PMC Article

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