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Hum Mutat. 2016 Oct;37(10):1042-50. doi: 10.1002/humu.23040. Epub 2016 Aug 23.

Deep Genetic Connection Between Cancer and Developmental Disorders.

Qi H1,2, Dong C3,4, Chung WK5, Wang K3,4, Shen Y6,7,8.

Author information

1
Department of Applied Physics and Applied Mathematics, Columbia University, New York, New York.
2
Department of Systems Biology, Columbia University Medical Center, New York, New York.
3
Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California.
4
Biostatistics Division, Department of Preventive Medicine, University of Southern California, Los Angeles, California.
5
Departments of Pediatrics and Medicine, Columbia University Medical Center, New York, New York.
6
Department of Systems Biology, Columbia University Medical Center, New York, New York. ys2411@cumc.columbia.edu.
7
Department of Biomedical Informatics, Columbia University Medical Center, New York, New York. ys2411@cumc.columbia.edu.
8
JP Sulzberger Columbia Genome Center, Columbia University Medical Center, New York, New York. ys2411@cumc.columbia.edu.

Abstract

Cancer and developmental disorders (DDs) share dysregulated cellular processes such as proliferation and differentiation. There are well-known genes implicated in both in cancer and DDs. In this study, we aim to quantify this genetic connection using publicly available data. We found that among DD patients, germline damaging de novo variants are more enriched in cancer driver genes than non-drivers. We estimate that cancer driver genes comprise about a third of DD risk genes. Additionally, de novo likely-gene-disrupting variants are more enriched in tumor suppressors, and about 40% of implicated de novo damaging missense variants are located in cancer somatic mutation hotspots, indicating that many genes have a similar mode of action in cancer and DDs. Our results suggest that we can view tumors as natural laboratories for assessing the deleterious effects of mutations that are applicable to germline variants and identification of causal genes and variants in DDs.

KEYWORDS:

de novo mutations; developmental disorders; somatic mutation hotspots; tumor suppressors

PMID:
27363847
PMCID:
PMC5021574
DOI:
10.1002/humu.23040
[Indexed for MEDLINE]
Free PMC Article

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