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Anticancer Res. 2016 Jun;36(6):2659-64.

Decreased Expression of Retinoid X Receptors During Human and Azoxymethane-induced Colorectal Carcinogenesis in the Rat.

Author information

1
Susan Lehman Cullman laboratory for Cancer Research, Department of Chemical Biology, Earnest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, U.S.A. xhao@mail.nih.gov.
2
Susan Lehman Cullman laboratory for Cancer Research, Department of Chemical Biology, Earnest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, U.S.A.
3
Laboratory of Pathology, National Cancer Institute, Bethesda, MD, U.S.A.
4
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, MD, U.S.A.

Abstract

BACKGROUND/AIM:

The family of retinoid X receptors (RXRs) including RXRα, β and γ, is involved in regulating cell proliferation, differentiation, apoptosis and development.

MATERIALS AND METHODS:

In order to characterize the role of RXRs during colorectal carcinogenesis, the expression of RXRs in human and azoxymethane (AOM)-induced rat colorectal tumors was profiled by immunohistochemistry.

RESULTS:

Both human and rat normal colorectal epithelia and hyperplasia exhibited strong nuclear, but weak cytoplasmic staining for all three proteins. Expression of RXRα, β and γ was significantly reduced in rat carcinomas compared to high-grade dysplasia whether in aberrant crypt foci or in adenomas. All three proteins displayed dramatically reduced nuclear expression in both human adenomas and carcinomas. Reduced expression of RXRα and RXRγ seems more significant than RXRβ in both human and rat carcinomas.

CONCLUSION:

Reduced expression of RXRs is associated with colorectal carcinogenesis in both humans and AOM-treated rats.

KEYWORDS:

RXRs; carcinogenesis; colonic cancer; immunohistochemistry

PMID:
27272774
[Indexed for MEDLINE]

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