Format

Send to

Choose Destination
See comment in PubMed Commons below
Allergy. 2016 Nov;71(11):1620-1625. doi: 10.1111/all.12942. Epub 2016 Jul 13.

The Patient-Oriented Eczema Measure in young children: responsiveness and minimal clinically important difference.

Author information

  • 1Bristol Randomised Trials Collaboration, School of Social and Community Medicine, University of Bristol, Bristol, UK. daisy.gaunt@bristol.ac.uk.
  • 2Bristol Randomised Trials Collaboration, School of Social and Community Medicine, University of Bristol, Bristol, UK.
  • 3Centre for Academic Primary Care, School of Social and Community Medicine, University of Bristol, Bristol, UK.

Abstract

BACKGROUND:

The Patient-Oriented Eczema Measure (POEM) has been recommended as the core patient-reported outcome measure for trials of eczema treatments. Using data from the Choice of Moisturiser for Eczema Treatment randomized feasibility study, we assess the responsiveness to change and determine the minimal clinically important difference (MCID) of the POEM in young children with eczema.

METHODS:

Responsiveness to change by repeated administrations of the POEM was investigated in relation to change recalled using the Parent Global Assessment (PGA) measure. Five methods of determining the MCID of the POEM were employed; three anchor-based methods using PGA as the anchor: the within-patient score change, between-patient score change and sensitivity and specificity method, and two distribution-based methods: effect size estimate and the one half standard deviation of the baseline distribution of POEM scores.

RESULTS:

Successive POEM scores were found to be responsive to change in eczema severity. The MCID of the POEM change score, in relation to a slight improvement in eczema severity as recalled by parents on the PGA, estimated by the within-patient score change (4.27), the between-patient score change (2.89) and the sensitivity and specificity method (3.00) was similar to the one half standard deviation of the POEM baseline scores (2.94) and the effect size estimate (2.50).

CONCLUSIONS:

The Patient-Oriented Eczema Measure as applied to young children is responsive to change, and the MCID is around 3. This study will encourage the use of POEM and aid in determining sample size for future randomized controlled trials of treatments for eczema in young children.

KEYWORDS:

Patient-Oriented Eczema Measure; atopic eczema; minimal clinically important difference; paediatrics; responsiveness

PMID:
27232584
PMCID:
PMC5113674
DOI:
10.1111/all.12942
[PubMed - in process]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center