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Genome Med. 2016 May 23;8(1):58. doi: 10.1186/s13073-016-0317-9.

Environment-driven somatic mosaicism in brain disorders.

Author information

1
Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
2
Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA. gage@salk.edu.

Abstract

The identification of somatic mosaicism in the brain lends a new perspective to our understanding of the role of gene and environment interactions in psychiatric disease risk. Somatic mutations, such as retrotransposon insertions, that are precipitated by modern environmental factors may alter neuronal function and neurological traits, increasing the societal prevalence of mental disorders.

PMID:
27215330
PMCID:
PMC4877941
DOI:
10.1186/s13073-016-0317-9
[Indexed for MEDLINE]
Free PMC Article

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