Format

Send to

Choose Destination
Nat Rev Neurosci. 2016 Jul;17(7):424-37. doi: 10.1038/nrn.2016.46. Epub 2016 May 19.

Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience.

Author information

1
Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, California 92037, USA.

Abstract

The scarcity of live human brain cells for experimental access has for a long time limited our ability to study complex human neurological disorders and elucidate basic neuroscientific mechanisms. A decade ago, the development of methods to reprogramme somatic human cells into induced pluripotent stem cells enabled the in vitro generation of a wide range of neural cells from virtually any human individual. The growth of methods to generate more robust and defined neural cell types through reprogramming and direct conversion into induced neurons has led to the establishment of various human reprogramming-based neural disease models.

PMID:
27194476
PMCID:
PMC6276815
DOI:
10.1038/nrn.2016.46
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center