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Am J Emerg Med. 2016 Aug;34(8):1452-4. doi: 10.1016/j.ajem.2016.04.026. Epub 2016 Apr 23.

Intravenous lipid emulsion in the resuscitation of cocaine-induced cardiovascular arrest in a rat model.

Author information

1
Division of Medical Toxicology, Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA 01655.
2
Department of Emergency Medicine, Alpert Medical School at Brown University/Rhode Island Hospital, Providence, RI 02903. Electronic address: Jason_hack@brown.edu.

Abstract

CONTEXT:

Intravenous lipid emulsion (ILE) is a potential antidote for severe overdose of certain lipophilic drugs. Cocaine overdose is often fatal and has no antidote. The use of ILE after cocaine-induced cardiac arrest has been suggested but is not well characterized.

OBJECTIVE:

The objective of the study is to determine if ILE would reverse cocaine-induced cardiac arrest in a rat model.

MATERIALS AND METHODS:

Twelve Sprague-Dawley rats with intra-arterial and intravenous access were sedated with isoflurane and split into 2 cocaine dose groups, then given either ILE or normal saline (NS) intravenously (IV)-group A, 7 animals received cocaine (10 mg/kg IV) with 6 of 7 given ILE (15 mg/kg IV) and 1 of 7 given NS (equal volume); group B, 5 animals received cocaine (5 mg/kg IV) with 3 of 5 given ILE (15 mg/kg IV) and 2 of 5 given NS (equal volume). Closed chest compressions were initiated for asystole and continued for 15 minutes with rhythm checks every minute.

RESULTS:

All 12 rats experienced cardiac arrest after cocaine bolus. Resuscitation was successful in 1 of 7 rats in group A and 0 of 5 in group B.

CONCLUSIONS:

Intravenous lipid emulsion administration did not affect outcome of cocaine-induced cardiac arrest compared with control in this model.

PMID:
27142757
DOI:
10.1016/j.ajem.2016.04.026
[Indexed for MEDLINE]

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