Lower limit of normal based spirometric abnormalities associated with radiographic abnormality in an elderly cohort at low risk for exposure

Int J Occup Environ Health. 2016 Apr;22(2):121-7. doi: 10.1080/10773525.2016.1176328. Epub 2016 May 4.

Abstract

Background: Although the relation between radiographic abnormalities and spirometric impairment in people with asbestosis has been studied extensively, the extent of spirometric impairment associated with milder radiographic abnormalities is not established.

Objective: To test associations between mild radiographic abnormalities and Lower Limit of Normal (LLN)-based spirometry interpretation.

Methods: Spirometry and CXRs were collected for 1,026 at low risk of exposure to pneumoconiotic agents participants in a medical screening program.

Results: Individuals with each type of isolated or combined International Labour Organization (ILO) abnormalities had up to over sixfold statistically significant increase in odds of LLN-based restrictive pattern physiology (OR = 1.96, 95%CI 1.03-3.73 for parenchymal to OR = 6.09, 95%CI 1.94-19.10 for parenchymal and pleural) compared to those with normal films.

Conclusions: The findings from this study confirm the association of mild profusion abnormalities with clinically relevant, LLN-based lung function abnormalities.

Keywords: ILO; Lower limit of normal; Pneumoconiosis; Spirometric abnormalities; Spirometry.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Forced Expiratory Volume
  • Humans
  • Lung / diagnostic imaging
  • Lung / pathology
  • Lung Diseases / diagnostic imaging*
  • Lung Diseases / pathology
  • Lung Diseases / physiopathology*
  • Male
  • Middle Aged
  • Occupational Exposure
  • Parenchymal Tissue / diagnostic imaging
  • Parenchymal Tissue / pathology
  • Pleura / diagnostic imaging
  • Pleura / pathology
  • Radiography
  • Smoking / pathology
  • Smoking / physiopathology
  • Spirometry
  • Vital Capacity